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NEURO PRAX TMS/tES*

NEURO PRAX® TMS/tES systems measure physiological signals such as EEG, EMG, and EP simultaneously and synchronously for all channels. Unique amplifier technology captures EEG activity from infraslow (0 - 0.3 Hz) to ultrafast (80 - 1,200 Hz) frequencies.

The high amplifier dynamics and the high sampling rate make the NEURO PRAX® TMS/tES system particularly suitable for EEG measurement during transcranial magnetic stimulation (rTMS) and transcranial electrical stimulation (tES) with tDCS, tACS and tRNS.

The high-performance full-band DC-EEG provide a wide range of software-based functions such as the online correction of artifacts caused by muscle and eye movements, topographical analyses, spectral and amplitude mapping and online averaging.

The NEURO PRAX® TMS/tES is a biofeedback device according to the FDA Regulation Number 882.5050. It supports researchers to learn to self-regulate their brain activity (EEG biofeedback). It is intended to be used for EEG biofeedback with the slow cortical potentials (SCP) protocol.

Combining non-invasive brain stimulation with neuroimaging

Simultaneous recording of DC- EEG during non-invasive brain stimulation (NIBS), such as transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS, tRNS) or transcranial magnetic stimulation (TMS) is a painless method to evaluate the modulation of cortical oscillatory brain activity and cerebral plasticity. These methodologies allow neuroscientists to investigate a broad range of research topics, such as:

  • establishing a causal link between brain functions and behavior
  • understanding the online mechanisms of brain stimulation
  • assessing how non-invasive brain stimulation locally affects neural processing by means of objective measures of cortical activity, reactivity, and connectivity
  • determining in vivo the brain areas directly or indirectly affected by non-invasive brain stimulation
  • improving stimulation protocols based on direct effects to brain activity

The neuroConn DC-STIMULATOR PLUS* and NEURO PRAX® TMS/tES* work hand in hand to provide noisefree EEG while stimulating the brain with tDCS and even with tACS. The DC-STIMULATOR PLUS delivers a galvanically isolated reference signal of the applied stimulation, whilst NEURO PRAX® eliminates the stimulation-induced artefacts from all EEG channels in real time using an innovative correction software. The high dynamic range of 219 mV allows to record brain signals during tES without the EEG-amplifier going into saturation.

A worldwide unique solution for neuroscientists: The DC-STIMULATOR PLUS combined with the NEURO PRAX® TMS/tES* provide artifact-free EEG-tACS.

Noise-free EEG during tES: The worldwide unique neuroCare solution

Why combine EEG with tES (tDCS, tACS, tRNS)?

  • tES-EEG for functional neuroimaging in science and clinic
  • detailed understanding of tES-induced effects in motor and non-motor regions
  • detailed understanding of local and network effects of tES
  • discover brain-behavior relationships
  • guiding tES input parameters by monitoring brain states

NEURO PRAX® TMS/tES*: short recovery times of 3 - 5 ms after the TMS pulse allow correction of TMS-induced artefacts in realtime for all channels

Simultaneous EEG with TMS, even in combination with neuronavigation

Why combine EEG with TMS?

  • TMS-EEG for functional neuroimaging
  • better insights into cortico-cortical and interhemispheric interactions
  • detailed understanding of local and network effects of tES
  • more direct assessment of cortical inhibitory processes
  • deeper understanding of cortical plasticity
  • prospects of clinical applications

Noisefree tACS/tRNS EEG with NEURO PRAX® TMS/tES* and DC-STIMULATOR PLUS*

The combination of NEURO PRAX® TMS/tES* and the DC-STIMULATOR PLUS* with the option Signal Out now allows to measure a noise-free EEG during the stimulation with alternating or random noise current.

NEURO PRAX® TMS/tES* uses an integrated innovative correction software to eliminate the stimulation-induced noise from the EEG signals. Click on the picture for more detailed information.

Technical Data

Full-band DC-EEG and BIOSIGNAL AMPLIFIER
  • 32 full-band DC-channels (64, 128 channels)*
  • input impedance > 10 G
  • 24-bit resolution per channel
  • selectable sampling rates of 64 to 4,096 sps
  • frequency range of 0 to 1,200 Hz @ 4,096 Hz sampling rate
  • common mode rejection rate (CMRR) > 90 dB @ 50 Hz
  • dynamic input range approx. ±219 mV
  • input noise < 0.9 μV (RMS) @ 0 - 110 Hz at 256 sps
  • max. power consumption 1.5 W
  • continuous operation time > 8 h
  • power supply via built-in rechargeable batteries
  • applied part BF
  • dimensions in mm: 290 x 130 x 200 (W x D x H)
  • weight: 4.2 kg (incl. batteries)
  • data transmission via optical fiber
  • electrode input box, incl. connector cable (32, 64, 128 channels)
  • * optional
Panel-PC
  • powerful Intel™ Core Duo processor, min. 1 GB RAM, 160 GB hard disc, USB 2.0, ethernet interface (LAN), min. 15“ TFT color monitor, keyboard, mouse
  • operating system WINDOWS® 10 (and later)
  • operating voltage 100-240 V @ 60/50 Hz AC
  • dimensions in mm: 420 x 365 x 170 (W x D x H)
  • weight: 11.6 kg (incl. stand)

References

  • Brochure

    • neuroConn product portfolio for NIBS-EEG

  • Poster

    • Closed-loop application and artefact correction for tACS-EEG

  • Poster

    • Closed-loop apparatus for brain state-dependent tES: a proof of principle based on SMR

  • Poster

    • Overview of hardware artefacts during simultaneous tES and EEG

  • Poster

    • A Method for Online Correction of Artifacts in EEG signals during Transcranial Electrical Stimulation

Areas of Application

  • Biofeedback: DC-EEG biofeedback system, quantitative EEG, cognitive evoked potentials TMS/MEP MEP threshold detection
  • MEP brain mapping: (via the TMS navigation system Brainsight®)
  • TMS-EEG: quantitative EEG analysis and cognitive evoked potentials before, during and after transcranial stimulation, examinations relating to the safety of transcranial stimulation
  • tES/rTMS-EEG: recording and analysis of cortical and subcortical TMS-EEG activities, examination of the functional connectivity between areas of the brain, examination of TMS-induced modulation of brain rhythms, EEG-triggered TMS stimulation
Publications

Items marked with* are investigational devices and for research use only. CAUTION - Investigational Device. Limited by Federal (or United States) law to investigational use.