Rogue Research cTMS*

New cTMS for Research

Features of ElevateTMS

First new TMS design in years
Variable pulse shapes
Integrated EMG
Integrated output recording
Multiple general purpose triggers (4 in, 4 out), switch in, TTL out), External control via network
Optional current reversal module (~2 msec switching time)

Pulse Waveform Capabilities

Directionality Control: Controls amplitude of the -ve phase relative to the +ve phase
Variable pulse widths up to 385 μSec (with optional high inductance coil)
Monophasic, Biphasic, polyphasic, Staircase, Asymmetric
Repetition rates up to 1 kHz
Unidirectional theta burst
Charging power: 2X 1500 Joules per second

Thoughtful Coil Designs

Removable handles to suit every preference
Different inductances to extend cTMS pulse range
B-Field 3D mapped for use in E-field modelling research
Integrated coil tracker mount
More models to come (cooled coil, 50mm fig-8 etc.)

Pulse type (positive PW, negative PW)		M-Ratio	10 Hz	25 Hz	50 Hz	100 Hz	200 Hz	400 Hz	800 Hz	1 kHz	Maximum Output	Maximum Freq. (Hz) at Max Output
Unidirectional Biphasic Train	45µs,145µs	.2	100	100	49	24	11	N/A	N/A	N/A	100	24
	60µs, 185µs	.22	100	82	40	19	9	N/A	N/A	N/A	100	20
	75µs, 22µs	.25	93	55	27	13	6	N/A	N/A	N/A	93	15
Unidirectional Biphasic Train (balanced pulse)	11µs, 54µs	.76	100	100	100	100	100	100	65	49	100	550
	20µs, 78µs	.139	100	100	100	100	91	43	19	14	100	184
	30µs, 105µs	.162	100	100	100	91	44	20	N/A	N/A	100	91
	40µs, 131µs	.182	100	100	100	54	26	12	N/A	N/A	100	55
	50µs, 158µs	.198	100	100	70	34	16	N/A	N/A	N/A	100	35
	60µs, 185µs	.2165	100	97	47	23	10	N/A	N/A	N/A	100	24
	70µs, 212µs	.2365	97	66	32	16	7	N/A	N/A	N/A	24	17
	80µs, 238µs	.2599	78	57	28	13	6	N/A	N/A	N/A	85	18
	86µs, 255µs	.2756	78	47	23	11	N/A	N/A	N/A	N/A	78	15
Bi-directional	Positive 60µs, 100µs	1	43	43	43	26	13	5	N/A	N/A	43	63
Bi-directional	Negative 60µs, 100µs	1	43	43	43	21	10	4	N/A	N/A	43	50

References

Rogue Research cTMS

D’Ostilio, Kevin and Goetz, Stefan M and Hannah, Ricci and Ciocca, Matteo and Chieffo, Raffaella and Chen, Jui-Cheng A and Peterchev, Angel V and Rothwell, John C. (2016). Effect of coil orientation on strength--duration time constant and I-wave activation with controllable pulse parameter transcranial magnetic stimulation. Clinical Neurophysiology, 127(1), 675--683.
DOI 10.1016/j.clinph.2015.05.017

Goetz, Stefan M and Luber, Bruce and Lisanby, Sarah H and Murphy, David LK and Kozyrkov, I Cassie and Grill, Warren M and Peterchev, Angel V. (2016). Enhancement of Neuromodulation with Novel Pulse Shapes Generated by Controllable Pulse Parameter Transcranial Magnetic Stimulation. Brain stimulation, 9(1), 39.
DOI 10.1016/j.brs.2015.08.013

Hannah, R and Ciocca, M and Sommer, M and Hammond, P and Rothwell, J. (2014). P1067: Continuous theta burst stimulation with monophasic pulses: effect of current direction. Clinical neurophysiology(125), S332--S333.
DOI 10.1016/S1388-2457(14)51096-6

Peterchev, Angel V and DʼOstilio, Kevin and Rothwell, John C and Murphy, David L. (2014). Controllable pulse parameter transcranial magnetic stimulator with enhanced circuit topology and pulse shaping. Journal of neural engineering, 11(5), 56023.
DOI 10.1088/1741-2560/11/5/056023

Peterchev, Angel V and Goetz, Stefan M and Westin, Gregory G and Luber, Bruce and Lisanby, Sarah H. (2013). Pulse width dependence of motor threshold and input--output curve characterized with controllable pulse parameter transcranial magnetic stimulation. Clinical Neurophysiology, 124(7), 1364--1372.
DOI 10.1016/j.clinph.2013.01.011

Peterchev, Angel V and Jalinous, Reza and Lisanby, Sarah H. (2007). A transcranial magnetic stimulator inducing near-rectangular pulses with controllable pulse width (cTMS). IEEE Transactions on Biomedical Engineering, 55(1), 257--266.
DOI 10.1109/TBME.2007.900540

Peterchev, Angel V and Murphy, David L and Lisanby, Sarah H. (2011). Repetitive Transcranial Magnetic Stimulator with Controllable Pulse Parameters. Journal of neural engineering, 8(3), 36016.
DOI 10.1088/1741-2560/8/3/036016

Peterchev, AV and Murphy, DL and Lisanby, SH. (2010). Repetitive transcranial magnetic stimulator with controllable pulse parameters (cTMS). Conference proceedings:... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2010, 2922.
DOI 10.1109/IEMBS.2010.5626287

Sommer, M and Ciocca, M and Hannah, R and Hammond, P and Neef, N and Paulus, W and Rothwell, JC. (2014). P653: Intermittent theta burst stimulation inhibits human motor cortex when applied with mostly monophasic (anterior-posterior) pulses. Clinical neurophysiology(125), S228.
DOI 10.1016/S1388-2457(14)50747-X